The San Francisco 49ers suffered what appears to be another major injury blow on Sunday, this time to All-Pro linebacker Fred Warner

Warner got rolled up from behind while chasing down a run play against the Tampa Bay Buccaneers. His ankle twisted in an awkward direction, and he immediately clutched his lower leg in pain.

Trainers tended to Warner on the field and placed his injured lower leg into an air cast. He left the game on the back of the cart, and the 49ers quickly ruled him out for the rest of the game.