2025 NFL playoffs, odds, betting: San Francisco 49ers are biggest playoff underdogs in over 40 years against Seahawks The 49ers haven't been as big an underdog in the postseason in over 40 years as they are on Saturday against the Seahawks. Content Original Link: https://sports.yahoo.com/nfl/betting/article/2025-nfl-playoffs-odds-betting-san-francisco-49ers-are-biggest-playoff-underdogs-in-over-40-years-against-seahawks-195413675.html