Using matchup data, I’ve got 12 sleepers that could help your fantasy football teams get these much needed wins and help propel you toward the fantasy playoffs. Good luck and let’s go….
Quarterbacks
Jacoby Brissett vs. JAX
The Jags defense had a great showing against Justin Herbert last week but overall they’ve allowed the fifth-most fantasy points per game (FPPG) to the position.
They had given up 25+ fantasy points in three consecutive games prior to Week 11 where Matt Stafford started the party but quarterbacks like Geno Smith and Davis Mills came through and mopped up as well.
Brissett has put on the fantasy Superman cape: since becoming a starter in Week 6, he’s the QB8 in total scoring and the QB4 (!!!) in per game scoring, averaging 21.9 FPPG. I literally cannot believe I just typed that out.
Sam Darnold vs. TEN
Three of the last four quarterbacks the Titans have faced have scored 23+ fantasy points.
The Titans are especially weak at outside corner. They’ve allowed a 71.1% completion rate to outside receivers, ranking dead last, while also giving up the fifth-most yards. This bodes well for Darnold who should force feed Jaxon Smith-Njigba all game with reckless abandon.
Bryce Young vs. SF
The Niners are dead last in sacks per game and quarterback pressure rate this season. Consistently clean pockets have resulted in opposing quarterbacks torching this Niners defense.
The aforementioned Brissett was the latest of four consecutive quarterbacks to drop 20+ fantasy points against this defense (Stafford, Jaxson Dart, C.J. Stroud).
Young is coming off the best game of his NFL career: his 448 passing yards last week against Atlanta was a career high by a wide margin and he tossed three touchdowns for only the second time in his career, tying a career high.
DEEP SLEEPER: Shedeur Sanders vs. LV
The pass defense has been up-and-down but overall the Raiders have forced the second-lowest QB pressure rate. As a pure pocket passer, this bodes well for Sanders.
The stat line from Sanders' first NFL action in Week 11 was atrocious (4 of 16 for 47 yards and a pick) but when you watch the film, he honestly wasn’t as bad as the counting stats suggest. He played well on the handful of snaps where the offensive line didn’t immediately collapse. Ball placement was good and he showed A LOT more juice in his arm strength than Dillon Gabriel.
Running Backs
Alvin Kamara vs. ATL
Watch the injury report as Kamara is nursing an ankle injury but he was a limited participant on back-to-back practices to start the week.
If he’s good to go, he’s got a great matchup as the Falcons give up the fourth-most FPPG to the position. Six different running backs have scored 11+ PPR points in Atlanta’s past five games. This includes a 49-point PPR game to Colts RB Jonathan Taylor and a 39-point game to 49ers RB Christian McCaffrey.
The 4.1 yards after contact per carry allowed ranks as second-worst in the NFL.
Kamara is coming off one of his better rushing games this year when he ran for 83 yards against Carolina in Week 10.
Rhamondre Stevenson vs. CIN
Everyone is obviously goo-goo, ga-ga over TreVeyon Henderson but if Stevenson (toe) is healthy enough to play, he’s in a great spot. The Bengals have given up the most FPPG to opposing backs this season, including the most total touchdowns.
The 5.36 YPC allowed to RB’s ranks as third-worst and they’re dead last in run stuff rate.
While Henderson has been explosive and impressive, I wouldn’t be surprised in the least to see Stevenson in a 50-50 split.
Kenneth Gainwell vs. CHI
Jaylen Warren is working through an ankle injury; he posted a DNP and a LP to start the week of practice. Even if Warren plays, you figure he’ll be compromised somewhat, meaning Gainwell should have a healthy snap share.
The matchup is pristine. The Steelers have the fifth-highest outside run rate and the Bears have struggled mightily containing outside runs. Per Next Gen Stats, the 6.01 YPC allowed on outside runs ranks as second-worst and Chicago is fifth-worst in terms of explosive run rate allowed to the outside.
Wide Receivers
Cedric Tillman vs. LV
Kyu Blu Kelly has been BRUTAL as an outside corner and as a result the Raiders have allowed the fourth-most fantasy points per game to outside receivers, including the third-most receptions and yards.
I highlighted the lack of pressure generated by this defensive line earlier, and with Sanders in there, his increased arm strength can help unlock Tillman’s route tree.
Per Reception Perception, Tillman’s two most run routes were digs and slants where he also posted strong success rates. This pairs well with Sanders. His Reception Perception charting shows Shedeur favoring in-breaking routes as well.
Not counting screens and checkdowns, Sanders targeted players on in-breaking routes on 32.5% of his throws (just 18.2% on out-breaking routes).
Really like Cedric Tillman's skillset match with Shedeur. Per @RecepPerception, Tillman ran a ton of digs and slants last year and ran them well! Sanders meanwhile was terrific throwing inside as well and favored throwing in-breakers (1/2) pic.twitter.com/1J2R5sDig8
— James D Koh (@JamesDKoh) November 21, 2025
Jalen Coker vs. SF
Coker heads get hyped! Slot receivers have done serious work against the Niners. Greg Dortch of all folks scored a touchdown and posted 18.6 PPR points last week and slot men like Wan’Dale Robinson (13.6 PPR) and Jaylin Noel (11.3 PPR) have done reasonably well in recent weeks as well.
Overall, the Niners have given up the most FPPG to receivers lined up inside.
Michael Wilson vs. JAX
With Marvin Harrison Jr. out another week, let’s run it back with the guy who caught 15 passes for 185 yards last week.
The Jags have been blasted by outside wide receivers at various points this season and overall this secondary has allowed the third-most FPPG to receivers lined up outside.
The 48.5 projected total for this game suggests points could flow on both sides.
Rashid Shaheed vs. TEN
JSN is in a smash spot but the matchup is great for Shaheed as well. The Titans' 71.1% completion rate allowed to outside receivers ranks as dead last in the NFL. They’ve given up the fifth-most receptions, yards and fantasy points per game to the outside.
The Titans are also quite susceptible to giving up big plays. The 10.1 yards per pass attempt to outside receivers ranks as second-worst while the five touchdowns given up on deep passes is tied for the third-most. For a deep threat like Shaheed, he could be one big play away from being quite profitable in fantasy this week.
Tight Ends
Hunter Henry vs. CIN
Triple H has the pedigree to be a true TE1 this week. This is likely every fantasy analyst’s favorite streaming TE as the Bengals have been terrible defending the position, giving up the most fantasy points per game.
Eight different tight ends have scored double-digit PPR points against the Bengals over their past eight matchups.
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